Quick revision: every question with its correct answer. For the full explanation, open the test and tap View Solution.
3.1 Transgenic Animals — Test 1
Q1. A transgenic animal is one that:✓ Has a foreign gene stably integrated into its genome
Q2. The first transgenic mammal, the 'supermouse', was produced by introducing the gene for:✓ Growth hormone
Q3. Transgenic animals engineered to secrete valuable pharmaceutical proteins in their milk are often called:✓ Bioreactors (molecular pharming)
Q4. A key advantage of producing therapeutic proteins in transgenic animals rather than bacteria is that animals can:✓ Carry out complex post-translational modifications (e.g. glycosylation)
Q5. A knockout mouse, in which a specific gene is disrupted, is most useful as a:✓ Model to study the function of that gene and human disease
Q6. Transgenic pigs are being developed for xenotransplantation, which means using their organs for:✓ Transplantation into humans
Q7. GloFish, the fluorescent ornamental fish, are transgenic animals that express a:✓ Fluorescent protein gene
Q8. AquAdvantage salmon are transgenic fish engineered to:✓ Grow faster (reach market size sooner)
Q9. To direct a therapeutic protein into a transgenic animal's milk, the transgene is placed under the control of a:✓ Mammary-gland-specific promoter
Q10. The 'OncoMouse' was an early transgenic animal developed as a model for:✓ Cancer
Q11. Transgenic livestock can be engineered to improve traits such as:✓ Growth rate, milk yield or disease resistance
Q12. The integration of the transgene in a transgenic animal is verified at the DNA level by:✓ PCR or Southern blotting
Q13. Antithrombin (ATryn), an anticoagulant protein, was notably produced in the milk of transgenic:✓ Goats
Q14. A 'knock-in' transgenic animal carrying a human disease allele is used mainly to:✓ Model the human disease for study and drug testing
Q15. Compared with extraction from human or animal tissue, producing a protein in transgenic-animal milk offers:✓ A safer, scalable and renewable supply
Q16. Enviropig was a transgenic pig engineered to reduce environmental pollution by lowering the:✓ Phosphorus content of its manure
Q17. Transgenic animals used in research as disease models help scientists to:✓ Understand disease mechanisms and test new therapies
Q18. One major societal concern about transgenic animals relates to:✓ Animal welfare and ecological/ethical issues
Q19. Transgenic animals transmit the transgene to their offspring only if the transgene is integrated into the:✓ Germ-line (reproductive) cells
Q20. Match each transgenic animal/example with its purpose and select the correct option.✓ A-iii, B-iv, C-ii, D-i