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1.3 Haemostasis & Coagulation — Test 1
Q1. The anticoagulant most commonly used in blood banks to store donated blood is:✓ Sodium citrate
Q2. The basic, final reaction in the clotting of blood is the:✓ Conversion of fibrinogen to fibrin
Q3. Which blood-clotting factor acts after fibrin has formed, to stabilise the clot?✓ Factor XIII (fibrin-stabilising factor)
Q4. High doses of antibiotics can kill gut bacteria and lead to impaired:✓ Blood coagulation (via reduced vitamin K)
Q5. Which vitamin is necessary for normal blood clotting?✓ Vitamin K
Q6. Thrombosis (excessive clotting) can be best related to which vitamin's status?✓ Vitamin K
Q7. Which one of the following is NOT a blood coagulation factor?✓ Baker factor
Q8. During inflammation, the chemical mediator of pain is generated mainly by the:✓ Kininogen–bradykinin system
Q9. The organic matrix of bone is composed largely of the protein:✓ Collagen
Q10. Haemophilia, a bleeding disorder, most commonly results from deficiency of:✓ Factor VIII (antihaemophilic factor)
Q11. The intrinsic pathway of coagulation is initiated by:✓ Contact activation of factor XII on exposed collagen
Q12. The conversion of prothrombin to thrombin requires:✓ Calcium ions and activated factor X (prothrombin activator)
Q13. Plasmin, the enzyme that dissolves clots, is formed from:✓ Plasminogen
Q14. Calcium ions are essential for blood clotting because they:✓ Are required at several steps of the coagulation cascade
Q15. A clot that forms and remains attached at its site of origin in a vessel is called a:✓ Thrombus
Q16. Fibrinogen, the soluble precursor of fibrin, is mainly synthesised by the:✓ Liver
Q17. The first response of a small injured blood vessel that helps limit blood loss is:✓ Vascular spasm (vasoconstriction)
Q18. Hirudin, a natural anticoagulant, acts by inhibiting:✓ Thrombin
Q19. Match of clotting-factor names: Antihaemophilic factor = VIII; Stuart factor = X; Fibrin-stabilising factor = XIII; Tissue factor = III. This matching is:✓ Correct as stated
Q20. A deficiency of platelets in the blood (thrombocytopenia) leads to:✓ A tendency to bleed and bruise easily