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Extracellular Matrix — Test 1
Q1. The RGD motif in the extracellular-matrix protein fibronectin mediates:✓ Cell attachment
Q2. Integrins bind to extracellular-matrix proteins largely through the RGD motif found in:✓ Fibronectin
Q3. Which molecule acts as a general adhesive, connecting one cell to another and cells to other substrates?✓ Fibronectin
Q4. The glycoprotein laminin is mainly involved in:✓ Cell recognition and adhesion
Q5. Which of the following is NOT an extracellular-matrix protein?✓ Cyclin
Q6. Which of the following proteins is NOT related to the extracellular matrix?✓ Lamin
Q7. Collagen is the most prevalent ECM protein. Which statement about collagen is NOT true?✓ It is a triple helix of two α chains and one β chain wound together
Q8. Which characteristic is NOT true for fibronectin?✓ It is composed of three polypeptides disulfide-bonded into a cross-link
Q9. Which one of the following statements about glycosaminoglycans (GAGs) and proteoglycans is INCORRECT?✓ GAGs are long, branched polymers of sialic acid and glucose
Q10. Metastasis of cancer cells during malignant growth depends on which of the following enzymes?✓ Matrix metalloprotease
Q11. Which enzyme class is MOST important for normal collagen turnover in processes such as wound healing and bone development?✓ Proteases (e.g., collagenases / matrix metalloproteases)