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11.1 Apoptosis — Test 1
Q1. Apoptosis is:✓ A form of cell death
Q2. Apoptosis is characterized by:✓ Programmed cell death
Q3. Programmed cell death (apoptosis) is:✓ A genetically coded and regulated process
Q4. If serum is removed from a HEK cell culture, the cells will:✓ Undergo cell-cycle arrest
Q5. The terminal (executioner) caspase of the intrinsic pathway is:✓ Caspase 3
Q6. Apoptosis involves the activation of a series of enzymes called:✓ Caspases
Q7. Caspases, the effectors of apoptosis, belong to which family of enzymes?✓ Proteases
Q8. Which one of the following statements is correct with reference to apoptosis?✓ Apoptosis involves breakdown of the nuclear DNA
Q9. Which one of the following is true about the plasma membrane during cell death?✓ In apoptosis it stays intact, while it ruptures in necrosis
Q10. Which one of the following assay systems can specifically detect apoptotic cells?✓ FITC-Annexin V based FACS analysis
Q11. Which of the following methods can be used to selectively lyse newly dividing cells?✓ Bromodeoxyuridine (BrdU) labelling of dividing cells followed by exposure to light
Q12. Which one of the following, released from the mitochondria, nucleates formation of the apoptosome?✓ Cytochrome c
Q13. Which one of the following best describes death-upon-detachment of cells from the extracellular matrix?✓ Anoikis
Q14. Which of the following proteins acts as a death receptor that triggers the extrinsic pathway of apoptosis?✓ Fas
11.2 Regulation — Test 2
Q15. Which among the following are pro-apoptotic?✓ BID and BAX
Q16. A decrease in the Bcl-2 / Bax ratio will impact a cell by:✓ Inducing apoptosis
Q17. Given the proteins A. BCL-2, B. BCL-XL, C. A1, D. BAX — which is/are NOT anti-apoptotic?✓ D only
Q18. The following statements concern abnormally expressed proteins in human cancers:✓ B and D
Related Topics (Cancer, Senescence & Methods) — Test 3
Q19. Which term indicates the ability of a cancer to invade other parts of the body and produce secondary tumours?✓ Metastasis
Q20. The Dunn chamber is used to study cellular:✓ Chemotaxis
Q21. The number of times a normal somatic, differentiated human cell population will divide before cell division stops is known as the:✓ Hayflick limit
Q22. Which one of the following best defines an oncogene?✓ An oncogene is a dominantly expressed, mutated gene that renders a cell advantageous towards survival/proliferation
Q23. The main difference between normal and transformed (cancer) cells is:✓ Immortality and loss of contact inhibition
Q24. A homeotic mutation is one in which:✓ One cell type/structure follows the developmental path of another
Q25. Immortalization of mouse embryonic fibroblasts (MEFs) bypasses senescence/the Hayflick limit. Which method is most suitable to generate immortalized MEFs?✓ Transformation by overexpression of an oncogene
Q26. Which one of the following does NOT promote ageing in humans?✓ Activation of telomerase
Q27. Which of the following events will NOT usually lead to transformation of a normal cell into a cancer cell?✓ Gain of function of genes involved in nucleotide excision repair