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1.5 Genomic Tools — Test 1
Q1. Genomic imprinting refers to:✓ Parent-of-origin-specific gene expression
Q2. An androgenetic embryo (with only paternal chromosomes) in mammals tends to develop:✓ Extra-embryonic tissues well but a poor embryo
Q3. A gynogenetic embryo (with only maternal chromosomes) tends to develop:✓ The embryo proper but poor extra-embryonic tissues
Q4. Vital dyes are used in developmental biology mainly to:✓ Mark cells and follow their fate (fate mapping)
Q5. Reporter genes (such as GFP) are useful in development because they:✓ Reveal when and where a gene is expressed
Q6. A transgenic organism is one that:✓ Carries a foreign or modified gene introduced experimentally
Q7. A knockout mouse is made to:✓ Inactivate a specific gene and study the resulting phenotype
Q8. The Cre–lox system is used in development to:✓ Delete or alter a gene in specific cells or at specific times
Q9. Forward genetics in development typically begins with:✓ A mutant phenotype, then finds the responsible gene
Q10. Reverse genetics in development means:✓ Starting from a known gene and making a mutation to see its effect
Q11. Chimeric mice (made by combining cells from two embryos) are useful to:✓ Trace the contribution and fate of different cell populations
Q12. To determine the tissue lineage of a progenitor cell population, which method is NOT suitable?✓ Simply observing the embryo without any marking
Q13. DNA methylation is the main molecular mark used in:✓ Genomic imprinting