2.2 cAMP / Adenylate Cyclase Pathway

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2.2 cAMP / Adenylate Cyclase Pathway — Test 1

Q1. In the cAMP pathway, activated adenylate cyclase converts:✓ ATP to cyclic AMP

Q2. cAMP exerts most of its effects by activating:✓ Protein kinase A

Q3. cAMP is degraded to inactive 5'-AMP by the enzyme:✓ Phosphodiesterase

Q4. Caffeine is expected to augment the physiological actions of cAMP because it:✓ Inhibits phosphodiesterase

Q5. Which of the following hormones uses cAMP as its second messenger?✓ PTH

Q6. The action of ADH on the renal collecting duct (water reabsorption) is mediated through:✓ V2 receptors and cAMP

Q7. The second messenger for glucagon is:✓ cAMP

Q8. Match each hormone with its second-messenger system and choose the correct option.✓ A-iii, B-i, C-ii

Q9. Following PTH injection, an increase in URINARY cAMP indicates that:✓ The Gs-adenylate cyclase coupling at the PTH receptor is intact

Q10. beta1- and beta2-adrenergic receptors transmit their signal mainly through:✓ cAMP

Q11. The G protein that couples a hormone receptor to adenylate cyclase to RAISE cAMP is:✓ Gs (stimulatory)

Q12. A key advantage of the cAMP second-messenger system for a peptide hormone is that:✓ The hormone need not enter the cell to act

Q13. Which hormone uses cAMP, in contrast to GnRH which uses IP3?✓ ACTH

Q14. Phosphodiesterase inhibitors would be expected to:✓ Augment and prolong cAMP-mediated responses

Q15. The overall cAMP cascade order is:✓ Hormone -> Gs -> adenylate cyclase -> cAMP -> PKA -> phosphorylated proteins -> response

Q16. Which one of the following lists contains ONLY hormones that use the cAMP mechanism?✓ ACTH, TSH, glucagon, calcitonin

Q17. In the cAMP pathway, the specificity of the cellular response depends largely on:✓ Which proteins PKA phosphorylates in that cell

Q18. Cholera toxin raises intracellular cAMP because it:✓ Locks Gs in the active state

Q19. cAMP is best described as a:✓ Intracellular second messenger

Q20. In the parathyroid gland, the second messenger mediating PTH secretion is also:✓ cAMP