IP3 / Ca2+ Pathway

20 questions • 1 test • tap a section to begin

Welcome! 2.3 IP3 / Ca2+ Pathway — 20 questions, CSIR-NET style.

What this test covers

  • Gq → phospholipase C → DAG + IP3
  • IP3 releases Ca2+ from ER; DAG + Ca2+ activate PKC
  • Hormones: GnRH, TRH, GHRH, angiotensin II, ADH-V1, oxytocin, alpha1
  • Contrast with the cAMP pathway

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2.3 IP3 / Ca2+ Pathway — Test 1
Q1. In the IP3 pathway, the activated effector enzyme that splits membrane lipids is:✓ Phospholipase C
Q2. Phospholipase C liberates which two second messengers from membrane PIP2?✓ Diacylglycerol (DAG) and IP3
Q3. IP3 produces its main effect by:✓ Mobilizing Ca2+ from the endoplasmic reticulum
Q4. Diacylglycerol (DAG), together with released Ca2+, activates:✓ Protein kinase C (PKC)
Q5. Gonadotropin-releasing hormone (GnRH) acts on anterior-pituitary cells through:✓ The IP3/Ca2+ mechanism
Q6. The vascular (vasoconstrictor) action of ADH is mediated by:✓ V1 receptors and IP3/Ca2+
Q7. Oxytocin produces uterine contraction through the second-messenger system:✓ IP3 / Ca2+
Q8. Match each hormone with its second messenger and choose the correct option.✓ A-iii, B-i, C-ii
Q9. alpha1-adrenergic receptors signal mainly through:✓ IP3 / Ca2+
Q10. The intracellular store from which IP3 releases calcium is the:✓ Endoplasmic (sarcoplasmic) reticulum
Q11. Which of the following hormones uses IP3 rather than cAMP?✓ Angiotensin II
Q12. After phospholipase C acts, the component that REMAINS in the membrane and activates PKC is:✓ Diacylglycerol (DAG)
Q13. A lipid-soluble signalling molecule that nevertheless acts through a CELL-SURFACE receptor is:✓ Prostaglandin
Q14. The G protein that couples receptors to phospholipase C in the IP3 pathway is:✓ Gq
Q15. Rising cytosolic Ca2+ often acts by first binding the Ca2+-sensor protein:✓ Calmodulin
Q16. TRH stimulates TSH and prolactin secretion using the second messenger:✓ IP3 / Ca2+
Q17. The overall IP3 cascade order is:✓ Hormone -> Gq -> phospholipase C -> DAG + IP3 -> Ca2+ release / PKC -> response
Q18. DAG can also serve as a source of arachidonic acid, linking the IP3 pathway to the synthesis of:✓ Prostaglandins and leukotrienes
Q19. Which receptor/hormone pairing correctly uses the IP3/Ca2+ system?✓ Oxytocin receptor
Q20. Compared with the cAMP pathway, a distinctive feature of the IP3 pathway is that it:✓ Raises intracellular Ca2+ as part of the signal