4.2 Anterior Pituitary & POMC

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Welcome! 4.2 Anterior Pituitary & POMC — 20 questions, CSIR-NET style.

What this test covers

Anterior-lobe cell types and their hormones
TSH/LH/FSH glycoprotein family (shared α, unique β)
POMC → ACTH, MSH, β-lipotropin, β-endorphin
Hyperpigmentation and the MSH link

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4.2 Anterior Pituitary & POMC — Test 1

Q1. Which pituitary cell-hormone pairing is INCORRECT (a mismatch)?✓ Thyroid-stimulating hormone — corticotroph

Q2. TSH, LH and FSH belong to the same glycoprotein family. They share an identical:✓ α subunit

Q3. Pro-opiomelanocortin (POMC) is the precursor of all of the following EXCEPT:✓ Follicle-stimulating hormone

Q4. Which substance is derived from POMC?✓ Adrenocorticotropic hormone (ACTH)

Q5. Hyperpigmentation in primary adrenal insufficiency (Addison disease) occurs because:✓ Low cortisol raises ACTH/POMC, and the MSH fragment stimulates melanocytes

Q6. The β subunit of the glycoprotein hormones is responsible for:✓ The unique biological specificity of each hormone

Q7. Match each anterior-pituitary cell with its product and choose the correct option.✓ A-iii, B-i, C-ii

Q8. α-MSH and β-MSH are produced mainly in the intermediate lobe, which in adult humans is:✓ Rudimentary

Q9. ACTH is secreted by the:✓ Pituitary gland

Q10. Which pituitary hormone is structurally homologous to prolactin and human placental lactogen?✓ Growth hormone

Q11. The mismatched pair among the following is:✓ Luteinizing hormone — mammary gland

Q12. The α subunit shared by TSH, LH, FSH is also found in:✓ Human chorionic gonadotropin (hCG)

Q13. β-endorphin, an opioid peptide, is co-produced with ACTH because both derive from:✓ POMC

Q14. In secondary adrenal insufficiency (pituitary ACTH deficiency), hyperpigmentation is:✓ Absent (because ACTH/MSH is low)

Q15. Which anterior-pituitary hormone is NOT part of the glycoprotein (α/β) family?✓ Prolactin

Q16. The cell type that increases markedly in number in long-standing primary hypothyroidism is the:✓ Thyrotroph

Q17. POMC processing yields different end-products in different lobes because of:✓ Lobe-specific prohormone convertase enzymes

Q18. Which hormone pairing is correctly matched?✓ ACTH — adrenal cortex

Q19. Increased circulating ACTH would be expected in a patient with:✓ Chronic primary adrenal insufficiency (Addison disease)

Q20. Melanocyte-stimulating activity in humans is largely attributable to:✓ The MSH sequence contained within ACTH/POMC