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4.3 Growth Hormone — Test 1
Q1. Growth hormone is secreted in a pulsatile fashion, with the largest burst occurring during:✓ Deep (slow-wave) sleep
Q2. Which of the following INHIBITS growth-hormone secretion by the anterior pituitary?✓ Somatomedins (IGF-1)
Q3. Somatomedin C is another name for:✓ Insulin-like growth factor I (IGF-1)
Q4. Many growth-promoting actions of GH are mediated indirectly through:✓ Somatomedins (IGFs) generated in the liver
Q5. A direct ('diabetogenic') action of growth hormone is to:✓ Decrease glucose uptake and increase gluconeogenesis
Q6. Excess growth hormone BEFORE puberty (open epiphyses) causes:✓ Gigantism
Q7. Acromegaly (GH excess after puberty) can be treated with somatostatin analogues such as:✓ Octreotide
Q8. Match each factor with its effect on GH secretion and choose the correct option.✓ A-iii, B-i, C-ii
Q9. Laron dwarfism is caused by:✓ Growth-hormone receptor defect / failure to generate IGF-1 despite normal GH
Q10. The IGF-1 receptor signals via a mechanism similar to that of:✓ The insulin receptor (tyrosine kinase)
Q11. Growth hormone deficiency in children classically causes:✓ Short stature with delayed growth
Q12. GH secretion is increased by all of the following EXCEPT:✓ Hyperglycaemia
Q13. After a 7-foot patient with pituitary gigantism has the pituitary removed, lifelong replacement is needed mainly with:✓ Thyroid hormone and glucocorticoids (± GH)
Q14. Growth hormone uses a receptor that:✓ Lacks intrinsic kinase activity and recruits JAK (then STAT)
Q15. A direct action of GH on adipose tissue is to:✓ Increase lipolysis
Q16. IGF-1 promotes linear growth chiefly by acting on:✓ Chondrocytes of the epiphyseal growth plate
Q17. In acromegaly (post-pubertal GH excess), characteristic changes include:✓ Enlarged hands/feet, coarse facial features and glucose intolerance
Q18. Somatostatin inhibits GH secretion by:✓ Blocking the pituitary response to GHRH
Q19. A useful, more stable laboratory index of average GH activity is:✓ Serum IGF-1
Q20. Negative feedback on GH is exerted by both somatostatin release and:✓ IGF-1 acting on the pituitary and stimulating somatostatin