7.5 Gut & Incretin Hormones — RBR Life Science

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Welcome! 7.5 Gut & Incretin Hormones — 20 questions, CSIR-NET style.

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7.5 Gut & Incretin Hormones — Test 1

Q1. The hormone that causes release of bile (gallbladder contraction) is:✓ Cholecystokinin (CCK)

Q2. The incretin effect refers to the fact that:✓ Oral glucose triggers more insulin than IV glucose, via gut hormones

Q3. The two main incretin hormones are:✓ GIP and GLP-1

Q4. Ghrelin, the 'hunger hormone', is:✓ A powerful appetite stimulant that peaks before meals

Q5. Leptin, a regulator of appetite, is secreted by:✓ Adipocytes throughout the body

Q6. Leptin inhibits the appetite-promoting NPY/AgRP neurons in the arcuate nucleus, signalling:✓ Satiety (reduced food intake)

Q7. Match each gut hormone with its main action and choose the correct option.✓ A-iii, B-i, C-ii

Q8. Which tissue does NOT normally produce ghrelin?✓ Liver

Q9. GLP-1 analogues are useful in type 2 diabetes because GLP-1:✓ Enhances glucose-dependent insulin secretion and slows gastric emptying

Q10. Secretin is released in response to acid entering the duodenum and stimulates:✓ Pancreatic bicarbonate secretion

Q11. Gastrin's principal action is to:✓ Stimulate gastric acid (HCl) secretion

Q12. Which hormone secreted from adipocytes promotes insulin resistance?✓ RBP4 (and resistin)

Q13. Resistin, which promotes insulin resistance, is produced from:✓ Adipocytes

Q14. In Prader-Willi syndrome, extreme hyperphagia is associated with:✓ High ghrelin levels

Q15. The arcuate nucleus integrates appetite signals; leptin and insulin act there to:✓ Reduce appetite (anorexigenic)

Q16. Cholecystokinin (CCK) is released in response to:✓ Fat and protein in the duodenum

Q17. DPP-4 inhibitors lower blood glucose by:✓ Prolonging the action of endogenous GLP-1/GIP

Q18. Which adipose hormone improves insulin sensitivity (opposite to resistin)?✓ Adiponectin

Q19. The glucose-dependent action of GLP-1 on insulin secretion means it:✓ Stimulates insulin only when glucose is elevated (low hypoglycaemia risk)

Q20. The overall role of incretins and adipose hormones is to:✓ Integrate gut and fat signals with insulin secretion and appetite