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3.6 Linkage, Recombination & Molecular Markers β Test 2
Q1. The frequency of crossing over between two genes is directly proportional to the:β Distance between the genes
Q2. In a genetic map, the distance between two genes is measured in:β Centimorgans (map units)
Q3. The maximum recombination frequency that can be observed between two loci is:β 50%
Q4. A genetic map built from recombination-frequency data is called a:β Linkage map
Q5. The number of linkage groups in a human male is:β 24
Q6. If an organism has 12 linkage groups, its haploid chromosome number is:β 12
Q7. After meiosis, 20% of the gametes are recombinant for two genes. The map distance between them is:β 20 cM
Q8. Genes A and B are 10 cM apart. In a test cross of AB/ab (cis), the proportion of AB/ab (parental) offspring of that type is about:β 45%
Q9. A two-point test cross of two UNLINKED genes gives a phenotypic ratio of:β 1:1:1:1
Q10. The ratio of the observed number of double crossovers to the expected number is the:β Coefficient of coincidence
Q11. Recombination does NOT occur during meiosis in:β Drosophila males
Q12. Which molecular marker is NON-PCR-based?β RFLP
Q13. A LOD score of 3 corresponds to odds in favour of linkage of:β 1000 to 1
Q14. The most suitable marker class for marker-assisted selection of agronomic traits is generally:β EST-SSR (expressed-sequence microsatellites)
Q15. Interspecific somatic-cell hybrids (e.g. human-mouse) have been especially useful for:β Physical gene mapping (assigning genes to chromosomes)
Q16. The fusion of human and mouse cells to make somatic-cell hybrids is commonly mediated by:β Inactivated Sendai virus (or PEG)
Q17. A molecular marker generally CANNOT be used directly for:β Identifying the expressed protein product
Q18. Neurospora is an ideal organism for determining whether allele segregation occurred at the first or second meiotic division because it:β Retains the ordered products of meiosis in an ascus
Q19. In Neurospora, second-division segregation patterns in the ascus are used to measure the distance between a gene and its:β Centromere
Q20. Match each term with its description and select the correct option.β A-ii, B-iv, C-i, D-iii