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9.2 Epigenetics, Chromatin & Genomic Imprinting β Test 1
Q1. The chemical basis of genomic imprinting is:β Methylation of DNA
Q2. The classic example of epigenetic regulation of transcription is:β DNA methylation
Q3. Methylation of CpG islands near a promoter inhibits transcription mainly by:β Facilitating heterochromatin formation / blocking activator binding
Q4. CpG islands (potential DNA-methylation sites) in mammalian genomes are:β More frequent than expected by chance near gene promoters
Q5. Tri-methylation at which histone residue is a repressive mark associated with Polycomb silencing?β H3K27
Q6. A histone modification commonly associated with transcriptional repression is:β Methylation of H3K9 (H3K9me)
Q7. Methylated histone marks are 'read' by proteins containing which domain?β Chromodomain
Q8. Which is NOT a common histone modification in eukaryotes?β Sulphonation
Q9. Which statement about epigenetics is TRUE?β It does not involve any change in the DNA sequence
Q10. The inheritance of a trait based on differences in DNA-methylation pattern (rather than sequence) is called:β Epiallelic inheritance
Q11. The study of heritable changes in gene expression that do not involve changes in DNA sequence (and geneβenvironment interplay) is:β Epigenetics
Q12. In mammalian females, the inactive X chromosome is maintained partly by:β DNA methylation (and repressive histone marks)
Q13. Genomic imprinting is best described as:β Differential expression of an allele depending on its parent of origin
Q14. A human disorder that is a classic example of genomic imprinting is:β Prader-Willi syndrome
Q15. A well-known imprinted gene is:β IGF-2 (insulin-like growth factor 2)
Q16. Which statement about imprinted genes in mammals is TRUE?β A copy is transcriptionally active in a parent-of-origin-specific manner
Q17. Prader-Willi syndrome arising when a child inherits two chromosome-15 copies from one parent illustrates:β Genomic imprinting via uniparental disomy
Q18. A mouse heterozygous for an IGF-II mutation has a size depending on whether the wild-type allele came from the mother or the father. This is:β Genomic imprinting
Q19. The histone variants H2A.Z, CENP-A, MacroH2A, H2A.X and H3.3 are associated, respectively, with:β Active promoters; centromeres; X-inactivation; DNA damage; active transcription
Q20. Match each epigenetic feature with its role and select the correct option.β A-ii, B-i, C-iv, D-iii