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1.3 Hematopoiesis β Test 1
Q1. In adults, haematopoiesis normally occurs in the:β Bone marrow
Q2. The correct sequence of fetal haematopoietic sites is:β Yolk sac β liver/spleen β bone marrow
Q3. A widely used surface marker of human haematopoietic stem cells is:β CD34
Q4. A defining property unique to haematopoietic stem cells is:β Self-renewal
Q5. Erythropoietin, the main regulator of red-cell production, is produced chiefly by the:β Kidney
Q6. The growth factor that drives platelet production from megakaryocytes is:β Thrombopoietin
Q7. The cytokine essential for both B- and T-lymphocyte development is:β IL-7
Q8. G-CSF (granulocyte colony-stimulating factor) primarily stimulates production of:β Neutrophils
Q9. Megakaryocytes give rise to:β Platelets
Q10. During erythrocyte maturation, the developing red cell:β Extrudes its nucleus
Q11. B lymphocytes complete their maturation in the:β Bone marrow
Q12. T lymphocytes complete their maturation in the:β Thymus
Q13. Monocytes that migrate into tissues differentiate into:β Macrophages
Q14. Haematopoiesis is regulated by:β Cytokines/growth factors and the marrow stromal niche
Q15. The common lymphoid progenitor can give rise to all EXCEPT:β Erythrocytes
Q16. IL-3 is sometimes called 'multi-CSF' because it:β Supports several myeloid lineages
Q17. GM-CSF promotes the development of:β Granulocytes and macrophages
Q18. Dendritic cells in haematopoiesis arise:β Mainly from myeloid (and some lymphoid) progenitors
Q19. Extramedullary haematopoiesis (in liver/spleen) in an adult usually indicates:β Increased demand or marrow failure
Q20. Match each growth factor with the lineage it predominantly stimulates and select the correct option.β A-iii, B-iv, C-i, D-ii