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2.3 Dendritic Cells β Test 1
Q1. The principal function of dendritic cells is to:β Capture antigen and present it to activate naive T cells
Q2. Dendritic cells are uniquely able to:β Activate naive (antigen-inexperienced) T cells
Q3. Immature dendritic cells in peripheral tissues are specialised for:β Antigen capture (high endocytosis/phagocytosis)
Q4. Dendritic-cell maturation is triggered by recognition of:β PAMPs/DAMPs via pattern-recognition receptors (e.g. TLRs)
Q5. On maturation, dendritic cells migrate to lymph nodes guided by the chemokine receptor:β CCR7
Q6. Plasmacytoid dendritic cells are specialised producers of:β Type I interferons (IFN-Ξ±/Ξ²)
Q7. Langerhans cells are dendritic cells found in the:β Epidermis (skin)
Q8. Cross-presentation by dendritic cells allows them to:β Present exogenous antigen on MHC class I to prime CD8 T cells
Q9. Mature dendritic cells provide the 'second signal' to T cells through:β Co-stimulatory molecules such as B7 (CD80/CD86)
Q10. Follicular dendritic cells differ from conventional dendritic cells in that they:β Display intact antigenβantibody complexes to B cells in germinal centres
Q11. Dendritic cells influence the type of T-helper response by:β Secreting polarising cytokines (signal 3)
Q12. A tolerogenic role of dendritic cells is to:β Present self-antigen without co-stimulation, promoting tolerance
Q13. Conventional (classical) dendritic cells are most specialised for:β Antigen presentation and T-cell priming
Q14. The high potency of dendritic cells at priming naive T cells is due to their:β High MHC and co-stimulator expression plus migration to T-cell zones
Q15. Dendritic cells originate mainly from:β Haematopoietic precursors in the bone marrow
Q16. Dendritic cells are considered the key link between innate and adaptive immunity because they:β Sense pathogens innately and then initiate adaptive T-cell responses
Q17. Dendritic-cell-based cancer vaccines work by:β Loading patient dendritic cells with tumour antigen to prime anti-tumour T cells
Q18. A dendritic cell presenting antigen with strong co-stimulation will most likely cause a T cell to:β Become fully activated
Q19. The dendritic cell's name derives from its:β Long branching cytoplasmic processes (dendrites)
Q20. Match each dendritic-cell type/state with its feature and select the correct option.β A-ii, B-i, C-iv, D-iii