Quick revision: every question with its correct answer. For the full explanation, open the test and tap View Solution.
3.2 Epitopes — Test 1
Q1. An epitope (antigenic determinant) is:✓ The specific part of an antigen recognised by antibody or a receptor
Q2. The region of an antibody that binds the epitope is the:✓ Paratope
Q3. A conformational (discontinuous) epitope is formed by:✓ Residues brought together by protein folding
Q4. B-cell epitopes differ from T-cell epitopes in that B-cell epitopes are usually:✓ Recognised in their native (often conformational) form
Q5. T-cell epitopes are characteristically:✓ Short linear peptides presented on MHC molecules
Q6. An idiotope is:✓ A unique antigenic determinant within an antibody's variable region
Q7. Cross-reactivity between two antigens occurs when they:✓ Share identical or very similar epitopes
Q8. The number of epitopes on an antigen that antibody can bind is its:✓ Antigenic valence
Q9. Which technique mainly detects linear epitopes?✓ Western blotting (denatured, SDS-PAGE)
Q10. The part of an antigen-derived peptide that contacts the MHC molecule is called the:✓ Agretope
Q11. Most native B-cell epitopes on globular proteins are:✓ Conformational
Q12. Antigenic determinants recognised by antibodies are usually located:✓ On the surface of the antigen
Q13. Immunodominance describes the tendency of:✓ A few epitopes to elicit most of the response
Q14. The complementary relationship between epitope and paratope is based mainly on:✓ Non-covalent interactions and shape complementarity
Q15. An epitope recognised by a T cell must first be:✓ Processed and presented on an MHC molecule
Q16. An anti-idiotype antibody recognises:✓ Idiotopes in the variable region of another antibody
Q17. Carbohydrate antigens are recognised:✓ By antibodies (B-cell epitopes) but generally not by classical T cells
Q18. Denaturation of a protein typically:✓ Destroys conformational epitopes but may expose linear ones
Q19. The 'internal image' concept refers to an anti-idiotype antibody that:✓ Mimics the shape of the original antigen
Q20. Which statement about an epitope is correct?✓ It is the antigenic determinant recognised, interacting with the paratope by 3-D shape
Q21. An epitope recognised by an antibody is typically located:✓ On the antigen, contacting the combined variable regions of heavy and light chains
Q22. Match each term with its correct description and select the correct option.✓ A-ii, B-i, C-iv, D-iii