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3.3 Immunoglobulins β Test 1
Q1. A basic immunoglobulin monomer consists of:β Two identical heavy chains and two identical light chains
Q2. The antigen-binding fragment of an antibody is the:β Fab
Q3. Effector functions such as complement fixation and Fc-receptor binding reside in the:β Fc region
Q4. Papain digestion of IgG produces:β Two Fab fragments and one Fc fragment
Q5. Pepsin digestion of IgG yields:β A bivalent F(ab')2 fragment and degraded Fc
Q6. The most abundant immunoglobulin in normal human serum is:β IgG
Q7. The immunoglobulin that exists as a pentamer and is the first antibody produced in a primary response is:β IgM
Q8. The principal immunoglobulin of mucosal/exocrine secretions is:β IgA (secretory, dimeric)
Q9. The immunoglobulin that mediates immediate (type I) hypersensitivity is:β IgE
Q10. The J (joining) chain is found in:β Polymeric IgM and secretory IgA
Q11. The secretory component of IgA functions to:β Mediate transport across epithelium and protect against proteolysis
Q12. The only immunoglobulin that crosses the human placenta is:β IgG
Q13. Variability that defines antigen specificity is located in the antibody's:β Variable (V) regions of the heavy and light chains
Q14. Isotypic variation among immunoglobulins refers to differences in:β The constant regions that define the antibody class
Q15. Allotypic determinants of immunoglobulins are:β Inherited differences in constant regions that vary between individuals
Q16. The hinge region of an antibody provides:β Flexibility between the two Fab arms
Q17. Which immunoglobulin, together with IgM, is the major surface receptor on naive mature B cells?β IgD
Q18. Light chains of immunoglobulins are of two types:β Kappa (ΞΊ) and lambda (Ξ»)
Q19. Bence-Jones proteins in the urine of myeloma patients are:β Free immunoglobulin light chains
Q20. The antibody class able to cross the placenta is:β IgG
Q21. The first antibody class to appear in a primary immune response is:β IgM
Q22. The antigen-binding region of an antibody is located in the:β Fab region (variable domains of heavy and light chains)
Q23. The antibody that mediates type I (immediate) hypersensitivity is:β IgE
Q24. The antibody most efficient at complement fixation (classical pathway) is:β IgM
Q25. The immunoglobulin class with the longest serum half-life is:β IgG
Q26. The immunoglobulin class with the largest molecular weight is:β IgM
Q27. The immunoglobulin class that binds to mast cells is:β IgE
Q28. Which statement about IgG is correct?β It is the most abundant serum antibody, crosses the placenta and fixes complement
Q29. Which immunoglobulins contain a J chain?β IgA (dimer) and IgM (pentamer)
Q30. Which immunoglobulin is heat-labile?β IgE
Q31. The secretory component of secretory IgA is derived from:β Cleavage of the epithelial receptor used to transport IgA across the cell
Q32. The anti-Rh (anti-D) antibody is of which class?β IgG
Q33. IgA performs all of the following EXCEPT:β Crossing the placenta
Q34. Antibodies are secreted by:β Plasma cells
Q35. IgM is involved in all of the following EXCEPT:β Crossing the placenta
Q36. The additional polypeptide required for polymerisation of IgM monomers into a pentamer is the:β J chain
Q37. Antibody light chains are:β The same across the different antibody classes
Q38. The immunoglobulin predominant in secretions such as milk and saliva is:β IgA
Q39. Individuals unable to make the J protein of certain immunoglobulins would have frequent infections of the:β Intestinal tract
Q40. Which of the following statements is correct?β IgM and IgG fix complement, IgA is secretory, and IgE mediates immediate hypersensitivity
Q41. A typical antibody light chain consists of:β One constant (C) and one variable (V) region
Q42. Antibody classes (IgM, IgG, IgA, IgD, IgE) differ from one another mainly in their:β Heavy-chain constant regions (with associated functional differences)
Q43. Based on its heavy chain, which antibody class has multiple subclasses?β IgG
Q44. Members of the antibody protein family sharing common structural features are collectively called:β Immunoglobulins
Q45. Match each immunoglobulin with its key feature and select the correct option.β A-ii, B-i, C-iii, D-iv