Quick revision: every question with its correct answer. For the full explanation, open the test and tap View Solution.
6.3 Antigen Presentation β Test 1
Q1. The most potent professional antigen-presenting cell, able to prime naive T cells, is the:β Dendritic cell
Q2. The three professional antigen-presenting cell types are:β Dendritic cells, macrophages and B cells
Q3. Dendritic cells capture antigen in peripheral tissues and then:β Mature and migrate to lymph nodes to present to T cells
Q4. B cells are especially efficient at presenting antigen that:β They capture via their specific B-cell receptor
Q5. Co-stimulatory molecules B7-1/B7-2 (CD80/CD86) on a mature APC engage which receptor on the T cell?β CD28
Q6. Antigen presentation without adequate co-stimulation tends to induce:β T-cell anergy or tolerance
Q7. Cross-presentation by dendritic cells is important because it allows:β Priming of CD8 CTLs against antigens the DC did not synthesise
Q8. MHC class II expression on non-professional cells can be induced by:β IFN-Ξ³
Q9. The immunological synapse formed between a T cell and an APC functions to:β Organise receptors and signalling molecules for efficient activation
Q10. Linked recognition in T-dependent antibody responses means that:β The B cell and helper T cell recognise epitopes on the same antigen
Q11. A resting (immature) dendritic cell is specialised for:β Antigen capture rather than T-cell activation
Q12. CTLA-4 (CD152) on T cells differs from CD28 in that it:β Delivers an inhibitory signal, dampening T-cell activation
Q13. Superantigens cause excessive presentation-independent activation by:β Bridging MHC II and the TCR VΞ² region outside the peptide groove
Q14. Follicular dendritic cells (FDCs) in germinal centres differ from conventional dendritic cells in that they:β Display intact antigenβantibody complexes to B cells (not peptide to T cells)
Q15. The principal signal that licenses a dendritic cell to mature and upregulate co-stimulators is:β Recognition of PAMPs/DAMPs (e.g. via TLRs)
Q16. Why is co-stimulation an important safeguard?β It restricts full T-cell activation to contexts of genuine danger (infection)
Q17. Macrophages presenting antigen are particularly important for:β Reactivation of effector/memory T cells at sites of infection
Q18. A key reason dendritic cells, and not most other cells, prime naive T cells is that they:β Express high co-stimulation plus abundant MHC and migrate to T-cell zones
Q19. Presentation of lipid antigens (rather than peptides) to certain T cells is carried out by:β CD1 molecules
Q20. Which cells are professional antigen-presenting cells?β Dendritic cells
Q21. A helper T cell with CD4 interacts with:β A class II MHCβantigen complex
Q22. Match each cell/molecule with its role in presentation and select the correct option.β A-ii, B-iv, C-i, D-iii