7.2 Interferons — Test 1 — RBR Life Science

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7.2 Interferons — Test 1

Q1. Interferons are a family of cytokines named for their ability to:✓ Interfere with viral replication

Q2. Type I interferons include:✓ IFN-α and IFN-β

Q3. The single type II interferon is:✓ IFN-γ, produced mainly by T cells and NK cells

Q4. Type I interferons protect against viruses chiefly by:✓ Inducing an antiviral state in nearby cells

Q5. The main function of IFN-γ is to:✓ Activate macrophages and promote Th1 cell-mediated immunity

Q6. Interferons signal through which intracellular pathway?✓ The JAK–STAT pathway

Q7. Type I interferons enhance antiviral immunity by also:✓ Increasing MHC class I expression and boosting NK-cell activity

Q8. Plasmacytoid dendritic cells are notable for producing large amounts of:✓ Type I interferons

Q9. Interferons are induced when cells detect viral components such as:✓ Viral nucleic acids via pattern-recognition receptors

Q10. A therapeutic use of interferon-α is in the treatment of:✓ Certain viral infections (e.g. chronic hepatitis) and some cancers

Q11. A therapeutic use of interferon-β is in the treatment of:✓ Relapsing multiple sclerosis

Q12. IFN-γ deficiency or defects in its pathway predispose to:✓ Severe mycobacterial and other intracellular infections

Q13. Type III interferons (IFN-λ) are particularly important at:✓ Epithelial/mucosal surfaces (e.g. respiratory, gut)

Q14. Interferon-stimulated genes (ISGs) mediate the antiviral state by, for example:✓ Degrading viral RNA and inhibiting viral protein synthesis

Q15. A key way IFN-γ enhances antigen presentation is by:✓ Upregulating MHC class I and class II expression

Q16. Both type I and type II interferons can enhance the activity of:✓ NK cells and macrophages

Q17. Some viruses evade interferon responses by:✓ Blocking interferon production or downstream signalling

Q18. Interferons are classified as type I, II or III based on:✓ Their receptors and the cells/genes involved

Q19. A practical consequence of type I interferon's systemic effects is that therapy can cause:✓ Flu-like side effects (fever, malaise)

Q20. Match each interferon feature with its description and select the correct option.✓ A-ii, B-i, C-iv, D-iii